∑τћαη MacDonald n/a





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email to:
memacdon@ucalgary.ca


Research
My research interest is focused on Magnetic Resonance Imaging applications including: interventional device tracking, cerebrovascular imaging and imaging of aging. Below are some selected manuscripts and proceedings. Citation analysis availble at Google scholar.

Journal Publications

22. R. Williams, J. Specht, E. Mazerolle, M.R. Lebel, M.E. MacDonald, G.B. Pike. Correspondence between BOLD fMRI task activation and cerebrovascular reactivity across the cerebral cortex. Frontiers in Physiology - Medical Physics and Imaging 14 (May 2023), p. 1167148. DOI:10.3389/fphys.2023.1167148.

21. A. Addeh, F. Vega, P. Medi, R.J. Williams, G.B. Pike, M.E. MacDonald. Direct Machine Learning Reconstruction of Respiratory Variation Waveforms from Resting State fMRI Data in a Pediatric Population. NeuroImage 41 (April 2023), p. 119904. DOI:10.1016/j.neuroimage.2023.119904.

20. H. Kumar, K. Dixit, R. Sharma, M.E. MacDonald, N. Sinha, K. Kim. Closed-loop vasculature network design for bioprinting large, solid tissue scaffolds. Biofabrication 15 (2 February 2023), p. 024104. DOI:10.1088/1758-5090/acb73c.

19. M. Wilms, J.J. Bannister, P. Mouches, M.E. MacDonald, D. Rajashekar, S. Langner, N.D. Forkert. A Bidirectional Normalizing Flow Model of Brain Aging. 2022. DOI:10.1109/TMI.2022.3161947

18. D. Rajashekar, M. Wilms, M.E. MacDonald, M.D. Hill, S.P. Dukelow, N.D. Forkert. Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients. Stroke & Vascular Neurology, 2021. doi:10.1136/svn-2021-001091

17. M.E. MacDonald, G.B. Pike. Magnetic Resonance Imaging of Healthy Brain Aging: A Review. NMR in Biomedicine 2021; Article e4564, pp. 1-25.

16. R.J. Williams; M.E. MacDonald, E.L. Mazerole, G.B. Pike. The relationship between cognition and cerebrovascular reactivity: Implications for cognitive fMRI. Frontiers in Physics - Medical Physics and Imaging, Volume 9, Article 645249

15. L. Lo Vercio, K. Amador, J. Bannister, S. Crites, A. Gutierrez, M.E. MacDonald, J. Moore, P. Mouches, D. Rajasheka, S. Schimert, N. Subbanna, A. Tuladhar, N. Wang, M. Wilms, A. Winder, N.D. Forkert. Supervised machine learning tools: a tutorial for clinicians. Journal of Neural Engineering 2020, 16(6), 062001.

14. M.E. MacDonald, R.J. Williams, D. Rajashekar, R.B.S. Stafford, A. Hanganu, H. Sun, A.J.L. Berman, C.M. McCreary, R. Frayne, N.D. Forkert G.B. Pike. The Effect of Aging on Cerebral Blood Flow and Cortical Thickness with Application to Age Prediction. Neurobiology of Aging. 2020: 95:131-142

13. D. Rajashekar, M. Wilms, M.E. MacDonald, J. Ehrhardt, P. Mouches, R. Frayne, M. Hill, N.D. Forkert. High-resolution T2-FLAIR and non-contrast CT brain atlas of the elderly. Scientific Data. 2020: 7(56):

12. M.E. MacDonald, R.J. Williams, N.D. Forkert, A.J.L. Berman, C.R. McCreary, R. Frayne, G.B. Pike. Interdatabase Variability of Cortical Thickness Measurements. Cerebral Cortex. 2019; 29(8):3282-3293

11. H. Sun, Y. Ma, M.E. MacDonald, G.B. Pike. Whole Head Quantitative Susceptibility Mapping Using a Least-norm Direct Dipole Inversion Method. Neuroimage. 2018; 179:166-175

10. M.E. MacDonald, A.J.L. Berman, R.J. Williams, E.L. Mazerole, G.B. Pike. Modelling Hyperoxia-induced BOLD Signal Dynamics to Estimate Cerebral Blood Flow, Volume and Mean Transit Time. Neuroimage. 2018; 178:461-474

9. A.J.L. Berman, E.L. Mazerolle, M.E. MacDonald, N.P. Blockley, W. Luh, G.B. Pike. Gas-free Calibrated fMRI with a Correction for Vessel-Size Sensitivity. NeuroImage. 2018; 169, 176-188

8. M.E. MacDonald, P. Dolati, M. Eesa, A. Mitha, J.H. Wong, R. Frayne. Dynamic Phase Contrast Magnetic Resonance Imaging for the Assessment of Arteriovenious Malformation and Aneurysm Pressure. Magnetic Resonance Imaging, 2016; 34, 1322-1328

7. M.E. MacDonald, N.D. Forkert, G.B. Pike, R. Frayne. Phase Error Correction in Time-Averaged 3D Phase Contrast Magnetic Resonance Imaging of the Cerebral Vasculature. Public Library of Science ONE. 2016. 11(2):1-15

6. MacDonald ME, Dolati P, Mitha A, Essa M, Wong JH, Frayne R. Flow and Hemodynamic Alteration in a Giant Cerebral Aneurysm Treated with a Pipeline Stent. Radiology Case Reports. 2015;10(2):1-7

5. MacDonald ME, Frayne R. Cerebrovascular Magnetic Resonance Imaging: A Review of State-of-the-Art Approaches, Methods and Techniques. NMR in Biomedicine. 2015;28(7):767-791

4. MacDonald ME, Frayne R. Phase Contrast MR Imaging Measurements of Blood Flow in Healthy Human Cerebral Vessel Segments. Accepted to Physiological Measurement. 2015;36(7):1517–1527.

3. MacDonald ME, Stafford RB, Yerly J, Andersen LB, McCreary CR, Frayne R. Accelerated Passive MR Catheter Tracking into the Carotid Artery of Canines. Magnetic Resonance Imaging. 2013;31(1):120-129.

2. Swailes NE, MacDonald ME, Frayne R. Dynamic phantom with heart, lung, and blood motion for initial validation of MRI techniques. Journal of Magnetic Resonance Imaging. 2011;34(4):941-946.

1. MacDonald ME, Smith MR, Frayne R. Deconvolution with simple extrapolation for improved cerebral blood flow measurement in dynamic susceptibility contrast magnetic resonance imaging during acute ischemic stroke. Magnetic Resonance Imaging. 2011;29(5):620-629.

Links to Thesis

M.E. MacDonald. 2014. Quantitative Cerebrovascular Magnetic Resonance Imaging. PhD's Thesis. University of Calgary.

M.E. MacDonald. 2010. Passive Catheter Tracking into the Carotid Artery using Accelerated Magnetic Resonance Imaging. Master's Thesis. University of Calgary.

Selected Proceedings

46. M. Wilms, J.J. Bannister, P. Mouches, M.E. MacDonald, D. Rajashekar, N.D. Forkert. Bidirectional Modeling and Analysis of Brain Aging with Normalizing Flows. Machine Learning in Clinical Neuroimaging at MICCAI, Lima, Peru. October 4, 2020.

45. M.E. MacDonald, S. Scott, W.Q. Liu, Y. Zhang, L. Metz, G.B. Pike. The Impact of Multiple Sclerosis Lesion Tract Burden on the Cortex. 26th OHBM Scientific Meeting, Montreal, Canada. June 26-30, 2020. pp #401

44. S. Scott, M.E. MacDonald, D. Rajashekar, W.Q. Liu, H. Sun, L. Metz, Y. Zhang, G.B. Pike. A Clustering Analysis of MS Lesions with T1-T2-weighted, Diffusion, QSM, and MTR Imaging. 26th OHBM Scientific Meeting, Montreal, Canada June 26-30, 2020. pp #286

43. H. Sun, M.E. MacDonald, R.M. Lebel, G.B. Pike. Simultaneous T1-weighted imaging, R2* mapping, and QSM from a multi-echo MPRAGE sequence using a radial fan-beam sampling scheme at 3 Tesla. 28th ISMRM Scientific Meeting, Sydney, Australia April 18-23, 2020. pp #3207

42. M.A. McLean, R.M. Lebel, M.E. MacDonald, M. Boudreau, G.B. Pike. Accelerated quantitative magnetization transfer (qMT) imaging using compressed sensing and parallel imaging. 28th ISMRM Scientific Meeting, Sydney, Australia. April 18-23, 2020. pp #3137

41. M.E. MacDonald, D. Rajashekar, R.J. Williams, H. Sun, C.R. McCreary, R. Frayne, N.D. Forkert, G.B. Pike. Machine learning methods for age prediction using cortical thickness and cerebral blood flow. 25th OHBM Scientific Meeting, Rome, Italy. June 9-13, 2019. pp #2704

40. H. Sun, M.E. MacDonald, E.L. Mazerolle, K. Sabourin, G.B. Pike. Localization of GPi for MRgFUS pallidotomy: a comparison between high-resolution FGATIR, R2* and QSM at 3 T. 27th ISMRM Scientific Meeting, Montreal, Canada. May 11-16, 2019.

39. M.E. MacDonald, W.Q. Liu, S. Scott, C.P. Rockel, D. Rajashekar, J.L. Specht, H. Sun, G.B. Pike. White Matter Tract-Defined Lesion Loads in Relapsing-Remitting Multiple Sclerosis. 27th ISMRM Scientific Meeting, Montreal, Canada. May 11-16, 2019.

38. R.J. Williams, J. Specht, M.E. MacDonald, R.M. Lebel, E.L. Mazerolle, G.B. Pike. Accounting for vascular reactivity to clarify the role of the subcortical regions in attention. Submitted to the 24th OHBM Scientific Meeting June 16-21, 2018. #1761

37. M.E. MacDonald, N.D. Forkert, A. Hanganu, Y. Ma, R.J. Williams, H. Sun, R. Stafford, C.M. McCreary, R. Frayne, G.B. Pike. Cerebrovascular Brain Aging Examined with Arterial Spin Labelling and Applied to Age Prediction. 26th ISMRM Scientific Meeting, Paris, France April 22-27, 2018.

36. R.J. Williams, E.L. Mazerolle, M.E. MacDonald, A.J.L. Berman, W.M. Luh, G.B. Pike. Flow and metabolic coupling associated with positive and negative BOLD responses across retinotopic early visual cortices. Submitted to the 3rd Imaging Cerebral Physiology Symposium, Cardiff, UK June 8-9, 2017.

35. M.E. MacDonald, R.J. Williams1, N.D. Forkert, A.J.L. Berman, C.M. Mc- Creary, R. Frayne, G.B. Pike. Consistency of Inter-Database Cortical Thinning with Age. 25th ISMRM Scientific Meeting, Honolulu, HI April 22-27, 2017. Abstract #0188

34. A.J.L. Berman, E.L. Mazerolle, M.E. MacDonald, N.P. Blockley, W.M. Luh, G.B. Pike. Correcting for imperfect spin echo refocusing in gas-free fMRI calibration. 25th ISMRM Scientific Meeting, Honolulu, HI April 22-27, 2017. Abstract #1661

33. H. Sun, Y. Ma, M.E. MacDonald, G.B. Pike. Tikhonov regularization aided quantitative susceptibility mapping of whole brain without background field removal. 25th ISMRM Scientific Meeting, Honolulu, HI April 22-27, 2017. Abstract #3668

32. M. Mclean, M.E. MacDonald, R.M. Lebel, M. Boudreau, G.B. Pike. Accelerated Z-Spectrum Imaging. 25th ISMRM Scientific Meeting, Honolulu, HI April 22-27, 2017. Abstract #1205

31. R.J. Williams, E. Mazerolle, M.E. MacDonald, W.M. Luh, G.B. Pike. Positive and negative BOLD and CBF responses across the early visual regions. Accepted to the 22nd Organization of Human Brain Mapping Annual Meeting, Geneva, Switzerland June 26-30, 2016. Abstract#: 2732

30. H. Sun, M.E. MacDonald, Y. Ma, G.B. Pike. Regularization-aided susceptibility inversion without background field removal. Submitted to the 4th Quantitative Susceptibility Mapping Workshop, Graz, Austria September 26-28, 2016.

29. R.J. Williams, E. Mazerolle, M.E. MacDonald, W.M. Luh, G.B. Pike. Positive and negative BOLD and CBF responses across the early visual regions. Accepted to the 22nd Organization of Human Brain Mapping Annual Meeting, Geneva, Switzerland June 26-30, 2016. Abstract#:2732

28. M.E. MacDonald, A.J.L. Berman, R.J. Williams, E.L. Mazerolle, G.B. Pike. Modeling Resting Cerebral Perfusion from BOLD Signal Dynamics During Hyperoxia. 24th ISMRM Scientific Meeting, Singapore City, Republic of Singapore. May 7-13, 2015. pp. 3831

27. H. Sun M.E. MacDonald, G.B. Pike. Phase Correction of a Bipolar Gradient-Echo Acquisition for Quantitative Susceptibility Mapping. 24th ISMRM Scientific Meeting, Singapore City, Republic of Singapore. May 7-13, 2015. pp. 2987

26. M.E. MacDonald, N.D. Forkert, G.B. Pike, R. Frayne. The Impact of Phase Errors on Mapping the Flow of the Cerebral Vasculature with Phase Contrast MRI. 21st OHBM Scientific Meeting, Honolulu, Hawaii, USA. June 14-18, 2015. pp. 2431

25. M.E. MacDonald, A.J.L. Berman, R.J. Williams, E.L. Mazerolle, G.B. Pike. Bold Oxygenation Level Dependence (BOLD) Quantitative Susceptibility Mapping (QSM) at Different Head Orientations. 23rd ISMRM Scientific Meeting, Toronto, Canada. May 30-June 5 2015. pp 2120

24. M.R. Smith, P. Adipour, J. Woehr, M.E. MacDonald. Overcoming the Image Position-Dependent Resolution Inherent in DFT and CS Reconstructions. 23rd ISMRM Scientific Meeting, Toronto, Canada. May 30-June 5 2015.

23. E. Lee, M.E. MacDonald, R. Frayne. Enhanced Dynamic Contrast Enhanced (DCE) MR for Brain Perfusion Imaging. 4th Canadian Stroke Congress, Montreal, 17-20 Aug 2013. pp 28

22. A. Eilaghi, D.A. McLean, D.G. Gobbi, M.E. MacDonald, M.L. Lauzon, M. Salluzzi, R. Frayne. Quantitative Susceptibility Mapping in Human Brain with Normal Aging. 3rd International Workshop on MRI Phase Contrast and Quantitative Susceptibility Mapping, Duke University. Durham, N.C., USA. 6-8 October, 2014. pp 56

21. M.E. MacDonald, R. Frayne. Comparing Blood Flow on Contralateral Sides of the Brain. Submitted to 26th International Magnetic Resonance in Angiography Conference, Rome, Italy. 16-19 Sept 2014.

20. M.E. MacDonald, P. Dolati, J.H. Wong, R. Frayne. Blood Volume Flow Rates of Vessels in the Healthy Human Cerebral Vasculature. 22nd ISMRM Scientific Meeting, Milan, Italy. 10-16 May 2014. pp 1839

19. M.E. MacDonald, M.L. Lauzon, R. Frayne. Imaging Battery for Brain Quantification. 22nd ISMRM Scientific Meeting, Milan, Italy. 10-16 May 2014. pp 1513

18. M.E. MacDonald, E. Lee, T. Lee, J. Woehr, C. d’Esterre, M.R. Smith, R. Frayne. Dual Compartmental Fitting of Dynamic Susceptibility Contrast MRI in Early Ischemic Stroke. 22nd ISMRM Scientific Meeting, Milan, Italy. 10-16 May 2014. pp 4601

17. A. Eilaghi, M.E. MacDonald, C.R. McCreary, M.L. Lauzon, E.E. Smith, D.G. Gobbi, M. Salluzzi, R. Frayne. Characterization of Cerebral Microbleeds using Quantitative Susceptibility Mapping: Role of Imaging Clinical Trials of Dementia and Small Vessel Disease. 4th Molecular Function and Imaging Symposium, Ottawa, 27-28 June 2013. pp 21.

16. E. Lee, M.E. MacDonald, R. Frayne. Improving Dynamic Contrast Enhanced MR Perfusion Measurements by Appropriate Selection of Acquisition Parameters. 25th International Workshop on Magnetic Resonance Angiography, New York, United States. 20-23 August, 2013, pp 154

15. Smith MR, Woehr J, Marasco E, MacDonald ME. Impact of DFT Properties on the Inherent Resolution of Compressed Sensing Reconstruction Images. 24th Irish Signals and Systems Conference, Letterkenny, Ireland. 20-21 June, 2013

14. MacDonald ME, Lebel RM, Frayne R. Passive Magnetic Resonance Catheter Tracking with Spatial Wavelet and Temporal Constraints. 21th ISMRM Scientific Meeting, Salt Lake City, United States, 20-26 April 2013.

13. MacDonald ME, Menon B, Dolati P, Goyal M, Frayne R. Arterial Spin Labeling Applications of Ischemic Stroke. 3rd Canadian Stroke Congress, Calgary, Canada. 29 Sept - 03 Oct, 2012.

12. MacDonald ME, Swailies N, Smith MR, Nielsen J, Frayne R. The Cramer Rao Lower Bound of Magnetic Resonance Phase Image Acquisitions: Comparison with Bayesian Constrained Reconstruction. International Accelerated Magnetic Resonance Imaging Workship, Freiburg, Germany, 23-24 Sept 2012.

11. MacDonald ME, Dolati P, Wong J, Leung T, Nielsen J, Frayne R. Sensitivity of Phase Contrast Derived Velocity and Stress Fields to Receiver Bandwidth at the Circle of Willis. 24th Annual International Magnetic Resonance Angiography Club Meeting, Utrecht, Netherlands, 19-21 Sept 2012.

10. MacDonald ME, Adair D, Dolati P, Yerly J, Frayne R. Real-Time 3D MRI with Random Undersampling Trajectories to Visualize Endovascular Catheters and Contrast Inflow. 20th ISMRM Scientific Meeting, Melbourne, Australia, 5-12 May 2012. pp 2274.

9. MacDonald ME, Dolati P, Anderson L, McCreary CR, Wong J, Frayne R. Measurement of Perfusion during Transient Carotid Occlusion. 20th ISMRM Scientific Meeting, Melbourne, Australia, 5-12 May 2012. pp 1026.

8. Beladi S, McCreary CR, Smith EE, Lauzon ML, MacDonald ME, Frayne R. Quantitative Susceptibility Mapping as an Improved Biomarker for Cerebral Microbleeds in Small Vessel Disease. 20th ISMRM Scientific Meeting, Melbourne, Australia, 5-12 May 2012. pp 1027.

7. MacDonald ME, Anderson LB, McCreary CR, Frayne R. Catheter Tracking using Passive Magnetic Resonance Imaging into the Ascending Aorta. 23rd Annual International Magnetic Resonance Angiography Club Meeting, Banff, AB, Canada, 25-28 September 2011. pp 158.

6. Smith MR, MacDonald ME, Marasco E, Salluzzi M, Gauderon P, Frayne R. Which 1980s and 1990s super-resolution reconstruction ideas would prove useful when 2011s compressed sensing reconstruction is used for MR sparse angiography? 23rd Annual International Magnetic Resonance Angiography Club Meeting, Banff, AB, Canada, 25-28 September 2011. pp 141.

5. MacDonald ME, Lauzon ML, Nielsen J, Frayne R. Determining the Cramer Rao Lower Bound of Magnetic Resonance Imaging. Joint American Association of Medical Physicists (AAPM) and Canadian Organization of Medical Physicists (COMP) Scientific Meeting, Vancouver, Canada, July 31-Aug 4 2011. pp 3425.

4. MacDonald ME, Swailes N, Andersen LB, McCreary CR, Frayne R. Guidance to the Branching Vessels of the Aortic Arch with Passive MR Catheter Tracking. 19th ISMRM Scientific Meeting, Montréal, Canada, 7-13 May 2011. pp 771

3. MacDonald ME, Smith MR, Frayne R. Improving CBF Image Contrast with Frequency Extrapolation for DSC-MRI during Acute Stroke. 19th ISMRM Scientific Meeting, Montreal, Canada, 7-13 May 2011. pp 1976

2. MacDonald ME, Stafford RB, Lauzon ML, Frayne R. 2009. One step real-time image correction with GUSTO (Gradient-warp and UnderSampling Transform Operator). 18th Annual ISMRM Scientific Meeting, Stockholm, Sweden, 1-7 May 2010. pp 3109

1. Stafford RB, MacDonald ME, Frayne R. 2009. Real-Time Gradient Warp Correction with OpenGL NURBS Surfaces. 18th Annual ISMRM Scientific Meeting, Stockholm, Sweden, 1-7 May 2010. pp 3110

© 2023 Matthew Ethan MacDonald, Last updated 2023-10-01